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apalutamide will decrease the extent or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which might be CYP3A4 substrates may result in decrease publicity to those remedies.Belzutifan can be a CYP2C19 sub